“There is evidence that ageing is in part caused by accumulated DNA damage 76 .First, various endogenously arising DNA lesions accumulate with age in the nuclear and mitochondrial genomes of healthy mammals, including humans 42,76,77 . This may reflect not only ongoing DNA-damage induction but also declining DNA-repair capacity over time 68,73 .Second, patients with inherited DDR defects often display features of premature ageing (Supplementary Table 1).Third, work in various organisms has implicated growth hormone and insulin-like growth factor 1 signalling in regulating longevity, and notably, such signalling is downregulated in response to DNA damage”