“The novelist Thomas Wolfe, recalling a lifelong struggle with illness, wrote in his last letter, “I’ve made a long voyage and been to a strange country, and I’ve seen the dark man very close.” I had not made the journey myself, and I had only seen the darkness reflected in the eyes of others. But surely, it was the most sublime moment of my clinical life to have watched that voyage in reverse, to encounter men and women returning from the strange country—to see them so very close, clambering back.”