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“We are beginning to understand that by the time the conquistadors struck the Andes or Custer reached the Black Hills of South Dakota, only shadow populations of natives remained. The Indian wars got the headlines, but they were mopping-up operations. The shock troops were diseases, especially smallpox, aided by weeds and a few other members of catastrophic agriculture’s evolved coalition.”

Richard Manning, Against the Grain: How Agriculture Has Hijacked Civilization
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