Dystopia Land discussion

Hi all — new here, longtime dystopian reader. Been on a real kick lately with books that dig into genetic engineering and corporate control themes — stuff like Upgrade by Blake Crouch and Tchaikovsky's Dogs of War got me thinking about how differently authors handle "what happens when the created thing stops obeying its creator."
Curious what this group's all-time favorites are for that specific trope — engineered/enhanced beings turning on the people who made them? Always looking for the next read that does something interesting with it.
(Also an indie sci-fi author myself, working in this exact space — happy to share more if anyone's curious, just didn't want to lead with a pitch in my first post here!)

Welcome, Anthony - great trope to dig into. A few all-timers that handle it differently: Bacigalupi's The Windup Girl is probably the sharpest take on engineered beings plus corporate control - Emiko is literally property of the system that made her. Atwood's Oryx and Crake does the corporate-compound version, where the engineered creatures outlast their makers' intentions. For the quieter end, Ishiguro's Klara and the Sun and Never Let Me Go both center beings who never quite get to rebel - which is its own kind of unsettling. And the old-school root is Wells' Island of Doctor Moreau. Curious which flavor lands for you - the ones that fight back, or the ones that don't know they should?