David J. Linden > Quotes

“Experiements that have been devised to inflict even mild social pain (like exclusion form a group task or betrayal by a partner in a gambling game) have demonstrated significant activation of the sinula and the anterior cingulate cortex. Emotional pain isn't just a metaphor: In terms of brain activation, it partially overlaps with physical pain.”
― David J. Linden, The Compass of Pleasure: How Our Brains Make Fatty Foods, Orgasm, Exercise, Marijuana, Generosity, Vodka, Learning, and Gambling Feel So Good

“Clearly, Siberian reindeer are not fighting over drugged urine for its nutrative value.”
― David J. Linden, The Compass of Pleasure: How Our Brains Make Fatty Foods, Orgasm, Exercise, Marijuana, Generosity, Vodka, Learning, and Gambling Feel So Good

“The head/heart duality is a well-known cultural phenomenon. In everyday speech we use "heart" as a shorthand to refer to our emotional state or our faith and "head" to refer to cognition or reason. Should I follow my head or my heart? Both "head" and "heart," while they are literally the names of body parts, are commonly used to stand for nonbodily phenonmena, for mental processes. But what body part do we use when we want to refer explicitly to our coporeal self? Whe, the humble "ass," of course! Consider the seminal gangsta rappers Niggaz with Attitude, who in thier classic track "Straight Outta Compton" rhyme: "Niggaz start to mumble / They wanna rumble / Mix 'em and cook 'em in a pot like gumbo / Goin' off on a motherfucker like that / With a gat that's pointed at yo ass." Do the guys in NWA mean to say that a gun is literally pointed downward, at your tuchas? Of course not. We understand that in this context "ass" means "corporeal self.”
― David J. Linden, The Compass of Pleasure: How Our Brains Make Fatty Foods, Orgasm, Exercise, Marijuana, Generosity, Vodka, Learning, and Gambling Feel So Good

“Male Amazon river dolphins will even insert thier penises in each other's blowholes in the only known example of nasal sex.*

*I refuse to make the obligatory "blowjob" joke here. Science writing is very serious business.”
― David J. Linden, The Compass of Pleasure: How Our Brains Make Fatty Foods, Orgasm, Exercise, Marijuana, Generosity, Vodka, Learning, and Gambling Feel So Good

“How does stress influence the midbrain pleasure circuit (or the feeding control circuits)? The short answer is that we don't really know. However, there are some tantalizing initial clues. Recall that twenty-four hours after a single exposure to cocaine, the excitatory glutamate-using synapses recived by VTA dopamine neurons express LTP. This change, which will result in greater dopamine release in VTA target areas, could also be produced by nicotine, mophine, amphetamines, or alcohol. Amazingly, even breif exposure to stress (a rat's five-minute-long forced swim in cold water) also produced LTP of the VTA synapses that was indistinguishable from that evoked by drugs. What's more, the stress-induced LTP could be prevented by pretreatment with a corticosterone receptor blocker. This suggests that drugs and stress rewire the pleasure circuit in overlapping ways and that the stress response to trigger LTP in the VTA requires a stress hormone signaling loop from the brain to the body and back.”
― David J. Linden, The Compass of Pleasure: How Our Brains Make Fatty Foods, Orgasm, Exercise, Marijuana, Generosity, Vodka, Learning, and Gambling Feel So Good

“Human sexual and social behavior shares some similaries with that of rodents, but has some important differences as well. It shows much greater variability and individuality, for example, and is less closely tied to the olfactory system. At present, it is tempting to speculate that those of us with cheatin' hearts might have differences in brain dopamine, vasopressin, or oxytocin signaling when compared to our more faithful friends who have adopted the prairie vole lifestyle.”
― David J. Linden, The Compass of Pleasure: How Our Brains Make Fatty Foods, Orgasm, Exercise, Marijuana, Generosity, Vodka, Learning, and Gambling Feel So Good

“On average, dopamine receptor density is reduced in the VTA target regions of obese subjects as compared with those lean subjects (a characteristic that can be measured in a brain scanner). But the key question remains: Do obese individuals show reduced dopaminergic activation of VTA target areas in response to food? Is a blunted pleasure response to food involved in obesity?”
― David J. Linden

“I’ve never felt better. I’ve never been healthier…. I run four or five miles, four or five times a week, but I broke both my legs running too much last summer. I had stress fractures in both my tibias from running too much. You know, once you’re an addict, you’re always an addict, so just because I found something good to do doesn’t mean I’m not going to hurt myself doing it.”
― David J. Linden, The Compass of Pleasure: How Our Brains Make Fatty Foods, Orgasm, Exercise, Marijuana, Generosity, Vodka,Learning, and Gambling Feel So Good

“The developmental diaschisis hypothesis has important consequences for the treatment of autism. Developmental diaschisis opens the possibility that in early life, autism treatments may end op focusing on brain regions that were previously unsuspected to contribute to cognitive or social function, such as the cerebellum. For instance, failure of the cerebellum to predict the near future could make it hard for babies at risk for autism to learn properly from the world. Consistent with this, the most effective known treatment for autism is applied behavioral analysis, in which rewards and everyday events are paired with one another slowly and deliberately - as if compensating for a defect in some prediction process within the brain. Applied behavioral analysis works only on only about half of kids with autism. It might be possible to manipulate brain activity in the cerebellum to help applied behavioral analysis work better or for more kids.”
― David J. Linden, Think Tank: Forty Neuroscientists Explore the Biological Roots of Human Experience

“The fact that nonhuman primates aid unrelated others firmly disputes the idea that helping requires cultural transmission through religious, moral, or educational institutions. Indeed, in a study of more than one thousand primarily Muslim and Christian children from countries around the world, religiosity was inversely related to children’s generosity in sharing stickers.12 Children from more religious homes gave away fewer stickers than did children from less religious backgrounds. Of great interest is that religiosity was positively correlated with the children’s interest in punishing perceived bad behavior.”
― David J. Linden, Think Tank: Forty Neuroscientists Explore the Biological Roots of Human Experience

“The dorsomedial striatum, a subregion of the basal ganglia, seems to be critical to goal-directed behavior. If it is damaged, the rat’s behavior will quickly become habitual even after limited exposure to a new task. Conversely, damage to the neighboring dorsolateral striatum will lead the rat to be more goal-directed and it will never lapse into habit, even after prolonged training.”
― David J. Linden, Think Tank: Forty Neuroscientists Explore the Biological Roots of Human Experience

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Benefit Description
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Factor Why It Matters
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― David J. Linden, Think Tank: Forty Neuroscientists Explore the Biological Roots of Human Experience

“in 1932, coined the term “homeostasis” in his book The Wisdom of the Body.5 Cannon identified principles for an integrated system that tends to maintain relatively constant internal environments, including the idea that our regulatory systems are made of multiple components that are organized to work in concert to increase or decrease concentrations of critical nutrients and metabolic factors in the blood to achieve desirable levels. Such a constant environment enables our ability to migrate, run, hunt, work, or sleep independently of whether we happen to be eating, digesting, or fasting.”
― David J. Linden, Think Tank: Forty Neuroscientists Explore the Biological Roots of Human Experience

“The conscious perception of a taste can be referred to as a quale, a singular sensation, such as when licking table salt. Yet the taste qualia we experience are actually comprised of separate attributes. Taste quale may be subdivided into the components of sensory quality (sweet, sour, salty, savory/umami, bitter, and perhaps a few others such as water taste, malty taste, or mineral taste); intensity (weak to strong); location (such as a bitter taste on the tip of the tongue or a bitter taste on the back of the tongue); and temporal dynamics (a short-lived taste or a lingering aftertaste). These features of taste are typically combined in the brain with a food’s other oral sensory and olfactory properties to create its flavor, to help us identify and recognize the food, to help reassure us that what we are experiencing is edible, and to create an association with how we feel after eating so that we can recognize the food at our next encounter and remember whether it was satisfying or made us sick.”
― David J. Linden, Think Tank: Forty Neuroscientists Explore the Biological Roots of Human Experience

“Drugs of abuse alter the same brain circuits. The drive to seek out life-sustaining environmental cues like food and water is maintained because these substances activate the central players in the brain motivation circuit, dopamine-using neurons of the ventral tegmental area. These neurons manufacture the neurotransmitter dopamine and release it onto their downstream target cells in brain regions like the nucleus accumbens that are also important components of the motivation circuit. Dopamine neuron firing appears to signal the things we urgently need to survive, and dopamine cells become active in response to food, water, warmth, and even sex.”
― David J. Linden, Think Tank: Forty Neuroscientists Explore the Biological Roots of Human Experience

“Buy Old Gmail Accounts
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In today’s digital age, having an established online presence is crucial. Whether you’re a business owner, marketer, or just someone looking to diversify your online activities, old Gmail accounts can be a game-changer. But what exactly are these accounts? Why should anyone consider purchasing them? In this article, we’ll explore the ins and outs of buying old Gmail accounts that are fully secured and verified. Get ready to discover how these valuable assets can enhance your online ventures!

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Old Gmail accounts refer to email addresses that have been created and used for an extended period. These accounts often possess a history of activity, making them more established than newly made ones.

Users typically engage with these accounts for various personal or professional reasons over the years. This can include sending emails, subscribing to newsletters, or managing online services.

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― David J. Linden

“To test this they gave mice a first stroke in motor cortex and then waited a week before beginning retraining. As expected, the mice recovered only minimally because too much time had been allowed to pass before training was initiated. They then gave these same mice a second stroke in an area near to the original stroke, and, not surprisingly, the animals developed an even worse impairment. The surprising result was that with retraining the mice returned to normal levels of performance. In essence a previous stroke was treated with a new stroke. It should be made clear that this experiment was done to prove definitively that there is a sensitive period after stroke that allows training to promote full recovery at the level of impairment. It is clearly not a viable therapeutic option to induce a second stroke in patients after a first stroke. Other means will need to be found to have the same desired effect without causing more damage to the brain. One promising option is to combine drugs, such as the serotonin reuptake inhibitor Fluoxetine (Prozac), with training early after stroke.25 Another is to drastically increase the intensity and dosage of behavioral training that patients receive early after stroke. At the current time in the first weeks after stroke patients spend about 60 percent of their time alone and 85 percent of the time immobile.26 We know from basic science that hundreds, if not thousands, of movement repetitions are needed to induce detectable changes in motor cortex in animal models.27 Current therapy offers only about thirty!28”
― David J. Linden, Think Tank: Forty Neuroscientists Explore the Biological Roots of Human Experience

“To summarize, the movements we make are a bit more complicated than they might seem at first glance; they involve complex conversions between sensory predictions and motor actions. And the conversions themselves are constantly being tweaked as we learn more about ourselves and our environment. This learning is triggered by sensory prediction errors, or mismatches between what we expected to feel after moving and what we actually feel. Here we have explored this process of learning and culminated with the idea that to improve our future movements, our brain likely seeks advice from teaching systems embedded within our brain and spinal cord—namely, our reflexes.”
― David J. Linden, Think Tank: Forty Neuroscientists Explore the Biological Roots of Human Experience

“Francis Crick, co-discoverer of the structure of DNA, arguably the greatest discovery in biology in the twentieth century, famously said, “If you want to understand function, study structure.”
― David J. Linden, Think Tank: Forty Neuroscientists Explore the Biological Roots of Human Experience

“It may be, for example, that one key difference between the brains of straight women and lesbians is the function of a particular protein, like a voltage-sensitive potassium channel, that influences the electrical behavior of certain neurons in a brain circuit that influences sexual and gender-typical behavior.”
― David J. Linden, Think Tank: Forty Neuroscientists Explore the Biological Roots of Human Experience

“Here’s one useful hypothesis: when female fetuses and babies are exposed to higher levels of testosterone, their brains are partially masculinized, and this increases the chance that, later in life, they will become sexually attracted to women. Similarly, when male fetuses and babies are exposed to lower levels of testosterone, their brains become partially feminized, thereby increasing the chance that they will eventually become sexually attracted to men. There are several lines of evidence in support of this idea.”
― David J. Linden, Think Tank: Forty Neuroscientists Explore the Biological Roots of Human Experience

“Identical twins often look so similar that they are confused with one another—an occasional source of amusement. As a result, they may find that their teachers, friends, or even relatives tend to treat them in similar ways, either because they cannot tell the twins apart or because they subconsciously assume that two people who look so much alike are also similar in other respects. A similarity in interpersonal interactions of this type creates what behavioral geneticists call a “shared environment,” and it can confound the analysis of nature versus nurture. Additionally, as described below, identical twins do, in fact, tend to resemble one another on a wide range of personality traits and, perhaps in consequence, often develop an extraordinarily close bond with one another. This development leads to a second conundrum: maybe the close interpersonal relationship between many identical twins tends to reinforce their psychological similarities and suppress their differences.”
― David J. Linden, Think Tank: Forty Neuroscientists Explore the Biological Roots of Human Experience

“What differences can we observe in the brains of men and women? Can we use those differences to test the hypothesis that the brains of gay men are more likely to be partly feminized and the brains of lesbians are more likely to be partly masculinized? In”
― David J. Linden, Think Tank: Forty Neuroscientists Explore the Biological Roots of Human Experience

“Rinsing with glucose orally and spitting it out (that is, even without swallowing it) can cause an anticipatory release of insulin from the pancreas. This release is very small but has a large effect on lowering blood glucose during and after eating. Surprisingly, this occurs not only for sugar, but also for oral starch, such as we may find in bread, potatoes, or pasta.12 But it is not clear yet that we have starch taste receptors. We do, however, have the enzyme salivary amylase in our mouths that digests starch sufficiently to become a taste stimulus, which in turn can elicit anticipatory insulin release. Another oral response to carbohydrates involves performance enhancement. It is well known that human exercise performance is boosted when athletes eat glucose during competition”
― David J. Linden, Think Tank: Forty Neuroscientists Explore the Biological Roots of Human Experience

“Our brains are comprised of around eighty billion neurons interconnected to form an enormous network involving approximately five hundred trillion connections called synapses.”
― David J. Linden, Think Tank: Forty Neuroscientists Explore the Biological Roots of Human Experience

“What if a chemical, either found in nature or cooked up in a lab, could tap into the motivational circuit and drive dopamine neurons artificially from within the brain? Intriguingly, this may be exactly how drugs of abuse work. Although different drugs of abuse have distinct molecular targets and very different behavioral effects, they all drive the electrical activity of dopamine neurons or the release of dopamine from these cells (while nonaddictive brain-targeted drugs like Prozac do not).5”
― David J. Linden, Think Tank: Forty Neuroscientists Explore the Biological Roots of Human Experience

“The results in rodents suggest that there is something about ischemic stroke itself that induces a time-limited window of augmented responsiveness to training. Dramatic proof of this conjecture came from a recent experiment by Steve Zeiler and colleagues at Johns Hopkins University School of Medicine. They reasoned that a second motor cortical stroke might paradoxically reopen a sensitive period of responsiveness to training and promote full recovery from a previous first stroke. To test this they gave mice a first stroke in motor cortex and then waited a week before beginning retraining. As expected, the mice recovered only minimally because too much time had been allowed to pass before training was initiated. They then gave these same mice a second stroke in an area near to the original stroke, and, not surprisingly, the animals developed an even worse impairment. The surprising result was that with retraining the mice returned to normal levels of performance. In essence a previous stroke was treated with a new stroke. It should be made clear that this experiment was done to prove definitively that there is a sensitive period after stroke that allows training to promote full recovery at the level of impairment.
It is clearly not a viable therapeutic option to induce a second stroke in patients after a first stroke. Other means will need to be found to have the same desired effect without causing more damage to the brain. One promising option is to combine drugs, such as the serotonin reuptake inhibitor Fluoxetine (Prozac), with training early after stroke. Another is to drastically increase the intensity and dosage of behavioral training that patients receive early after stroke.”
― David J. Linden, Think Tank: Forty Neuroscientists Explore the Biological Roots of Human Experience

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Legal Considerations
Buying old Gmail accounts can be tempting for many businesses. But it is important to understand the legal considerations. Ignoring these can lead to serious consequences. Below are key points to consider.

Compliance With Regulations
Every country has its own laws regarding digital assets. Buying old Gmail accounts may fall under these laws. It is crucial to know if it is legal in your country. Check local regulations before making a purchase. Ignorance can lead to fines or legal action. Consider consulting with a legal expert. They can provide specific guidance. They ensure you are not violating any laws. This step is important for the safety of your business.

User Agreement Terms
Gmail accounts are subject to Google’s user agreement. This agreement outlines acceptable use of their services. Buying or selling accounts may violate these terms. Violating these terms can lead to account suspension. Or even permanent bans. Read and understand Google’s user agreement. Make sure you comply with all terms. This helps avoid potential risks. It protects your business from unforeseen issues.

Frequently Asked Questions
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Conclusion
Purchasing old Gmail accounts can be a smart choice. They offer established credibility and a history of reliable use. These accounts can save you time and effort. Ensure you buy from trusted sources. This helps avoid any future issues. Always prioritize security and proper usage.

Old Gmail accounts can boost your online presence and productivity. Make an informed decision and enjoy the benefits.”
― David J. Linden, Incomplete Echoes: Personal Memoirs, Imagined Worlds, and Unfinished Stories: Limited Edition

“the question of why some individuals learn motor skills faster than others; perhaps they have a better system of reflexes. More important, perhaps the motor deficits that accompany various movement disorders, such as stroke and cerebellar ataxia, are in part caused by patients’ inability to execute appropriate corrections to their movements, thus depriving their brains of an extremely knowledgeable teacher. This research suggests that encouraging patients to make mistakes while moving and reinforcing patient-driven feedback corrections to their movement errors may be one path toward neurorehabilitation. In other words, as neuroscientists, we hope that the fundamental insights we make concerning the brain will be translated into methods for improving human life.”
― David J. Linden, Think Tank: Forty Neuroscientists Explore the Biological Roots of Human Experience

“The ability to detect even familiar stimuli can usually be restored by a brief palate cleanser, which literally permits a recovery from desensitization sufficient to intensify a subsequent experience. It is hard for me to assess how much I am waxing poetic, but it seems to me that the brain’s ability—its need—to perceive by contrast may partly explain why our efforts to achieve perennial satisfaction have been largely unsatisfactory. Because the brain grades on a curve, endlessly comparing the present with what came just before, the secret to happiness may be unhappiness. Not unmitigated unhappiness, of course, but the transient chill that lets us feel warmth, the sensation of hunger that makes satiety so welcome, the period of near-despair that catapults us into the astonishing experience of triumph. The route to contentment is through contrast.”
― David J. Linden, Think Tank: Forty Neuroscientists Explore the Biological Roots of Human Experience