Somebody is giving words to your story. Sometimes deciding who will tell your story is as important as determining how it will be told.
So who is your point-of-view character? There are multiple ways to tell any story. Which set of eyes will provide the best choice for the reader to see your story evolve?
Here are some questions to ask yourself:
What do you want the reader to know?
Who is in position to be present during critical scenes?
Who has the most investment in the story's outcome?
Who will be changed by the story's events?
And lastly, what tone do you want your story to have?
An important exception: if the point of your story is to portray a world that is fragmented, unraveling, absurd or complex, perhaps it will be necessary to jump from one point-of-view to another to convey this feeling.
As you begin to write your story, take time to weigh the various possibilities. Maybe the main character's Uncle Joe would be the best pair of eyes through which to view this story.