Examples:

"The Tenth, Fifth, and Second are the best of the Doctors."

"Christopher Eccleston, Peter Davison, and Patrick Troughton were the best Doctor Whos."

Listen, kid, I was writing Doctor Who literature before you were at the Guardian Style Guide.

(Oh, obviously italics for the title of the programme. "Christopher Eccleston, Peter Davison, and Patrick Troughton were the best actors to play the lead in Doctor Who.")