“The history of HRT use dates back to 1966 and the success of Dr. Robert Wilson’s best-selling book Feminine Forever, which he promoted vigorously. The premise of the book was that it was as natural and necessary for a menopausal woman to replace estrogen as it was for a diabetic to replace insulin. Dr. Wilson preached that doing so would keep a woman young, healthy, and attractive. He went so far as to declare that the lack of eggs and decline of reproductive hormones in a menopausal woman was a “galloping catastrophe”5 that could only be averted by taking estrogen supplements. He explained that with estrogen supplements, “Breasts and genital organs will not shrivel. Such women will be much more pleasant to live with and will not become dull and unattractive.” According to Dr. Wilson’s son, Ronald, all of his father’s expenses to write Feminine Forever were paid for by Wyeth-Ayerst, the maker of the synthetic estrogen supplement Premarin. He also said that Wyeth-Ayerst financed his father’s organization, the Wilson Research Foundation, which had offices on Park Avenue in Manhattan.”