Smallpox Vaccination Quotes

“The deviation of man from the state in which he was originally placed by nature seems to have proved to him a prolific source of diseases. From the love of splendour, from the indulgences of luxury, and from his fondness for amusement he has familiarised himself with a great number of animals, which may not originally have been intended for his associates.

The wolf, disarmed of ferocity, is now pillowed in the lady's lap. The cat, the little tiger of our island, whose natural home is the forest, is equally domesticated and caressed. The cow, the hog, the sheep, and the horse, are all, for a variety of purposes, brought under his care and dominion.”
― Edward Jenner, Vaccination Against Smallpox

“On April 30 Lucy cheerfully reported that, after three days' illness, she was on the mend. Although she had no mirror, she could feel twenty pockmarks on her face. 'I am almost glad you do not see it.," she wrote, "I don't believe I should get one kiss and yet the doctor tells me it is very becoming.”
― Nancy Rubin Stuart, Defiant Brides: The Untold Story of Two Revolutionary-Era Women and the Radical Men They Married

“The word 'vaccination' comes from vacca, the Latin word for 'cow'. This is a poignant recapitulation of the history of vaccines. The first vaccine properly so called had, as its active ingredient, the cowpox virus, a close relative of smallpox that however was much less likely to cause severe, disfiguring or lethal disease. Edward Jenner observed that milkmaids, who were often exposed to cowpox, suffered a relatively mild disease, but would be immune to the much more serious smallpox.

In an experiment that would unlikely pass muster in the modern world, he infected James Phipps, then an 8-year-old, with cowpox. He suffered a mild and transient illness, but when he was later exposed to scabs from a smallpox patient, he proved immune.

Unlike the earlier practice of variolation, which has been practised in late Song dynasty China that sought to induce the cutaneous form of smallpox, variola minor, to protect against the more severe forms of smallpox (variola major), Jenner's vaccination used a less pathogenic virus.
He relied on what would later be called 'antigenic similarity', but which was at the time hardly understood.”
― Chris von Csefalvay, Computational Modeling of Infectious Disease: With Applications in Python