jim Rugg has a v. good post on his site about differences between digital and print colour, specifically the difference between the print and digital versions of Mike Mignola's Hellboy in Hell #1:
The function of print has changed dramatically in the last decade. I speak to many people who produce or want to produce printed editions because they are stuck in a 20th century mindset when print was a commercial or mass medium. A printed edition represents a certain validation or sense of a “real” object. This desire often supersedes any consideration of the nuance of printing as part of the creative process or for its expressive possibilities ...
Media guru Marshall McLuhan suggests that when a medium is no longer considered mass media, it needs to redefine itself or it becomes obsolete. I heard Art Spiegelman apply this notion to comics as “Comics now either will probably become an art form or disappear.”
http://jimrugg.com/?p=290
--mza.