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“The development of antibiotics is one of the most successful stories in the history of medicine, but it is unclear whether its ending will be a completely happy one. Fleming prophetically warned in his 1945 Nobel lecture that the improper use of penicillin would lead to its becoming ineffective. The danger was not in taking too much; it was in taking too little to kill the bacteria but “enough to educate them to resist penicillin.”
― Eric Lax, The Mold in Dr. Florey's Coat: The Story of Penicillin and the Modern Age of Medical Miracles