Julie

“Most of the death occurred in the thirteen weeks between mid-September and mid-December 1918. It was broad in space and shallow in time, compared to a narrow, deep war.”
― Laura Spinney, Pale Rider: The Spanish Flu of 1918 and How it Changed the World

“What Casanova’s finding meant was that, regardless of their culture, diet, social status or income, one in 10,000 people are particularly vulnerable to flu–a vulnerability that they inherit from their parents.”
― Laura Spinney, Pale Rider: The Spanish Flu of 1918 and How It Changed the World

“Assuming that you had a place you could call home, the optimal strategy was to stay there (but not immure yourself), not answer the door (especially to doctors), jealously guard your hoard of food and water, and ignore all pleas for help. Not only would this improve your own chances of staying alive, but if everyone did it, the density of susceptible individuals would soon fall below the threshold required to sustain the epidemic, and it would extinguish itself.”
― Laura Spinney, Pale Rider: The Spanish Flu of 1918 and How It Changed the World

“It was a fascinating hint that flu might have a heritable component, but other studies failed to replicate the finding. Then in January 2011, in the midst of the annual flu season in France, a two-year-old girl was admitted to the intensive care unit of the Necker Hospital for Sick Children in Paris, suffering from ARDS (acute respiratory distress syndrome). Doctors saved her life, and one of them, Jean-Laurent Casanova, sequenced her genome. He wanted to know if it held the key to why an otherwise healthy child had nearly died of a disease that most children shrug off. It turned out that the girl had inherited a genetic defect that meant she was unable to produce interferon, that all-important first-line defence against viruses. As a result, her besieged immune system went straight to plan B: a massive inflammatory response similar to the one pathologists saw in 1918.”
― Laura Spinney, Pale Rider: The Spanish Flu of 1918 and How It Changed the World