Mimi | Literary Devourer

“I read so I can live more than one life in more than one place.”
― Anne Tyler

“The Cycle of Addiction (What Keeps Us Stuck) The cycle of addiction, the second part of the Two-Part Problem, is a response to what’s happening at the root—that brings with it its own set of problems. Addiction is essentially a symptom of those root issues that becomes its own “disease”—when we use any substance or behavior to manage our underlying pain, and use it repeatedly, we enter into a cycle, or a feedback loop. To understand what the cycle of addiction is, or in the case of alcohol what would be classified as Alcohol Use Disorder (AUD), we need to look at how alcohol dependence is formed. When we consume alcohol, our body reacts to the substance by releasing artificially high levels of dopamine. Dopamine is the neurochemical of wanting and motivation, and it lives in the midbrain—the part of our brain that is tasked with ensuring our survival. Typically, our midbrain releases dopamine when we encounter something that keeps us alive or that aids in procreation, like when we eat a piece of chocolate or have good sex. Dopamine is released in order to tell our brain that some activity or substance is good for survival, and the higher the levels of dopamine that are released, the more we are programmed to repeat the activity. When dopamine floods into the brain, it sends a signal that the activity is good for survival, and in order to make sure we repeat the behavior, our brain releases another neurochemical called glutamate to lock in the memory of the event, so that we are wired to do it again.”
― Holly Whitaker, Quit Like a Woman: The Radical Choice to Not Drink in a Culture Obsessed with Alcohol

“behaviors. Alcohol becomes more important because drinking it excessively tricks a primitive, unconscious part of our brain into believing it’s more critical to our survival than it actually is. The artificially high levels of dopamine that flood the brain when we ingest alcohol begin a cascade of other reactions and responses. The brain has a hedonic set point (a term coined by Dr. Kevin McCauley), which means that it both needs a certain amount of dopamine to register pleasure, and is programmed to downgrade levels of dopamine when we receive too much pleasure. Our bodies are constantly trying to find stasis, or balance, and the hedonic set point is an example of that. When high levels of dopamine are regularly released into the system from chronic use of alcohol, the dopamine is down-regulated (or balanced) by something called corticotropin-releasing factor, or CRF—a hormone that makes us feel anxious or stressed. If we flood our system with higher-than-normal levels of dopamine, we also flood our system with higher-than-normal levels of CRF, or anxiety. Over time, when our system is assaulted by surges of dopamine, our hedonic set point goes up (requiring more dopamine to feel good), and things that used to register as pleasurable (like warm hugs or our children’s laughter) don’t release enough dopamine to hit that raised baseline. To boot, activities that normally relieve stress, like a bath or a brisk walk, also lose their effectiveness. Alcohol becomes the quickest way our body learns to handle anxiety (which begets more anxiety because alcohol is a depressant, and the body reacts to it by releasing cortisol and adrenaline, which means the net effect of a glass of wine is more stress, not less). Our bodies are adaptive, and they adapt to an environment that expects the effects of alcohol. So here we are: we start using alcohol because it gives us more pleasure than sex and does more for stress management than chamomile tea. Over time it gets wrapped up in our survival response, so we are motivated to drink with the same force that motivates us to eat—only the force is stronger than the desire to eat because our midbrain, which ranks everything based on dopamine, thinks we need alcohol more than food. That seems like enough fuckery to contend with, but there’s more to the story.”
― Holly Whitaker, Quit Like a Woman: The Radical Choice to Not Drink in a Culture Obsessed with Alcohol

“When we drink alcohol, artificially high levels of dopamine are released into the brain—a glass of wine will release more dopamine than good sex, good chocolate, or good coffee. The above-normal level of dopamine tells our brain that alcohol is really good at keeping us alive, and so the brain sends out higher levels of glutamate to lock in the experience. We remember the experience of drinking a cold glass of Chardonnay on a hot summer day more than we remember eating a slice of apple pie, or drinking a kale smoothie, because of this neurobiological process. If we drink enough alcohol over a long enough period of time, this cycle locks in, and our brains identify alcohol as necessary for survival. When the midbrain is working properly, it will normally prioritize fighting, procreating, and eating. But over time and with enough exposure, the midbrain will begin to identify alcohol as necessary for survival. If we drink enough alcohol, our midbrain will eventually elevate drinking alcohol above other survival”
― Holly Whitaker, Quit Like a Woman: The Radical Choice to Not Drink in a Culture Obsessed with Alcohol