Mimi | Literary Devourer

“Humans have what is called a triune brain, or a three-part brain. The midbrain or reptilian brain is the oldest part of our brain, where our survival instinct lives; the limbic or mammalian brain is where our emotions live; and finally the neocortex is our thinking brain. Adult humans with a fully developed neocortex are typically operating from the top down, from the neocortex down to the midbrain. This basically means we (normally) don’t bang each other on the sidewalk or resort to fistfights to settle disagreements at work because our moral, rational, thinking brain—the neocortex—asserts control over our base survival instincts. The neocortex, and specifically the prefrontal cortex, is where our judgment, personality, willpower, inhibition, social skills, morality, decision making, planning, and loads of other functions live. If the brain is a car, the survival response (midbrain) is the gas, and the prefrontal cortex is the brake. In alcohol addiction, the top-down control gets flipped, and the survival, animal instinct overrides the rational, thinking brain. This is due to two different causes. First, the prefrontal cortex loses its strength and volume; it’s like a muscle, and the chemical component of alcohol (it’s a neurotoxin, as in it attacks gray matter or the regions of the brain involved in sensory perception, memory, emotions, speech, decision making, and self-control), along with the consistent deferral to the survival instincts, weakens its function. So the part of our brain that is responsible for inhibiting actions (willpower), making decisions, moderating social behavior, constructing our personality, upholding our ethics, and planning our future goes offline. At the same time, the midbrain—which thinks only about the next fifteen seconds, not tomorrow or next year—”
― Holly Whitaker, Quit Like a Woman: The Radical Choice to Not Drink in a Culture Obsessed with Alcohol

“When we drink alcohol, artificially high levels of dopamine are released into the brain—a glass of wine will release more dopamine than good sex, good chocolate, or good coffee. The above-normal level of dopamine tells our brain that alcohol is really good at keeping us alive, and so the brain sends out higher levels of glutamate to lock in the experience. We remember the experience of drinking a cold glass of Chardonnay on a hot summer day more than we remember eating a slice of apple pie, or drinking a kale smoothie, because of this neurobiological process. If we drink enough alcohol over a long enough period of time, this cycle locks in, and our brains identify alcohol as necessary for survival. When the midbrain is working properly, it will normally prioritize fighting, procreating, and eating. But over time and with enough exposure, the midbrain will begin to identify alcohol as necessary for survival. If we drink enough alcohol, our midbrain will eventually elevate drinking alcohol above other survival”
― Holly Whitaker, Quit Like a Woman: The Radical Choice to Not Drink in a Culture Obsessed with Alcohol

“behaviors. Alcohol becomes more important because drinking it excessively tricks a primitive, unconscious part of our brain into believing it’s more critical to our survival than it actually is. The artificially high levels of dopamine that flood the brain when we ingest alcohol begin a cascade of other reactions and responses. The brain has a hedonic set point (a term coined by Dr. Kevin McCauley), which means that it both needs a certain amount of dopamine to register pleasure, and is programmed to downgrade levels of dopamine when we receive too much pleasure. Our bodies are constantly trying to find stasis, or balance, and the hedonic set point is an example of that. When high levels of dopamine are regularly released into the system from chronic use of alcohol, the dopamine is down-regulated (or balanced) by something called corticotropin-releasing factor, or CRF—a hormone that makes us feel anxious or stressed. If we flood our system with higher-than-normal levels of dopamine, we also flood our system with higher-than-normal levels of CRF, or anxiety. Over time, when our system is assaulted by surges of dopamine, our hedonic set point goes up (requiring more dopamine to feel good), and things that used to register as pleasurable (like warm hugs or our children’s laughter) don’t release enough dopamine to hit that raised baseline. To boot, activities that normally relieve stress, like a bath or a brisk walk, also lose their effectiveness. Alcohol becomes the quickest way our body learns to handle anxiety (which begets more anxiety because alcohol is a depressant, and the body reacts to it by releasing cortisol and adrenaline, which means the net effect of a glass of wine is more stress, not less). Our bodies are adaptive, and they adapt to an environment that expects the effects of alcohol. So here we are: we start using alcohol because it gives us more pleasure than sex and does more for stress management than chamomile tea. Over time it gets wrapped up in our survival response, so we are motivated to drink with the same force that motivates us to eat—only the force is stronger than the desire to eat because our midbrain, which ranks everything based on dopamine, thinks we need alcohol more than food. That seems like enough fuckery to contend with, but there’s more to the story.”
― Holly Whitaker, Quit Like a Woman: The Radical Choice to Not Drink in a Culture Obsessed with Alcohol

“I read so I can live more than one life in more than one place.”
― Anne Tyler