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THE ODDS OF a family like this one existing at all, much less one that remained intact long enough to be discovered, seem impossible to calculate.

The most dreadful thing, perhaps, about schizophrenia—and what most sets it apart from other brain conditions like autism or Alzheimer’s, which tend to dilute and dissipate a person’s most identifiable personality traits—is how baldly emotional it can be.

One of the consequences of surviving schizophrenia for fifty years is that sooner or later, the cure becomes as damaging as the disease.

The great break between Freud and Jung took place largely over the issue of the nature of madness itself. Early psychoanalysis’s greatest partnership was over. But the argument over the origins and nature of schizophrenia was only just beginning.