Jeffrey’s Reviews > The Aging Brain > Status Update
Jeffrey
is 33% done
Ch 4
Brain shrinkage in key areas of age related decline correlate with known loss of function:
Shrinking pre frontal cortex - loss of executive function
Shrinking hippocampus (in medial temporal lobe) - loss in episodic memory
Shrinking white matter (esp coherence as detected by DTI On MRI) - loss in processing speed, this hurts PFC and hippo too
— May 23, 2026 11:39AM
Brain shrinkage in key areas of age related decline correlate with known loss of function:
Shrinking pre frontal cortex - loss of executive function
Shrinking hippocampus (in medial temporal lobe) - loss in episodic memory
Shrinking white matter (esp coherence as detected by DTI On MRI) - loss in processing speed, this hurts PFC and hippo too
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Jeffrey’s Previous Updates
Jeffrey
is 42% done
Went back to Ch 3
Is aging a disease ?
No - everyone gets it (old) there isnt a “healthy” population
Yes - the dictionary definition seems to suggest it is a departure from YOUR norm. AND lobsters and hydras dont age! They keep growing and living until killed.
Mechanisms of cell damage
Energy intake
Free radicals
Mutations / loss of telomere length
— Jun 13, 2026 12:05PM
Is aging a disease ?
No - everyone gets it (old) there isnt a “healthy” population
Yes - the dictionary definition seems to suggest it is a departure from YOUR norm. AND lobsters and hydras dont age! They keep growing and living until killed.
Mechanisms of cell damage
Energy intake
Free radicals
Mutations / loss of telomere length
Jeffrey
is 42% done
Ch 5
Age-Related Declines
• Neural specificity - discriminating within tasks
• Neural variability - even when resting brain use varies and its not random, higher variability is associated with faster processing speed
• Neural inhibition - being able to screen out irrelevant info
• Default mode regulation - again when idling brain fxn in special areas declines
— Jun 03, 2026 07:19PM
Age-Related Declines
• Neural specificity - discriminating within tasks
• Neural variability - even when resting brain use varies and its not random, higher variability is associated with faster processing speed
• Neural inhibition - being able to screen out irrelevant info
• Default mode regulation - again when idling brain fxn in special areas declines
Jeffrey
is 16% done
Aging brain loses:
processing speed,
executive function
Episodic Memory - the right now and a day ago
But gains in
Crystalline function - long term memory, vocabulary
* fun fact chance of dying doubles every 8 years
— May 07, 2026 02:00PM
processing speed,
executive function
Episodic Memory - the right now and a day ago
But gains in
Crystalline function - long term memory, vocabulary
* fun fact chance of dying doubles every 8 years
