Marnia Robinson

“Remember those cocaine addicts whose dopamine receptors (the tiny hands that grab neurochemicals) decreased after repeated drug use? Cocaine blasts the reward circuitry so that it pumps out massive amounts of exciting dopamine. This accounts for the high. Then two things happen simultaneously. First, the high begins to fade as the brain disposes of the extra dopamine. Second, because so much excess dopamine can damage or kill nerve cells, the cells protect themselves by reducing the number of dopamine receptors (little “hands”) on their surfaces. If a thunderstorm rolls in, you close all the windows and wait for it to pass. That’s what the cells do, except they assume that another storm is on the way, and stay closed up for a while. The addict has lowered her sensitivity to dopamine—a substance that helped give her the high. Now our addict feels rotten. She has two choices: Take more cocaine to jack up her mood artificially by saturating the remaining dopamine receptors, or suffer withdrawal symptoms. Withdrawal symptoms arise when the reward circuitry is starving for dopamine. Whether you have too few receptors for dopamine, or too little dopamine circulating around the nerve cells, you get the same result. Your reward circuitry batteries are low, leaving you with an acute desire to feel normal again.”
― Marnia Robinson, Cupid's Poisoned Arrow: From Habit to Harmony in Sexual Relationships

“All the joy the world contains has come through wishing happiness for others. All the misery the world contains has come through wanting pleasure for oneself. —Shantideva, ninth-century Indian mystic”
― Marnia Robinson, Cupid's Poisoned Arrow: From Habit to Harmony in Sexual Relationships