Cook's Illustrated

“Roasted at 450° 1. Temperature at ¼” below surface: 189° 2. Temperature at midpoint: 160° 3. Temperature at center: 125° Weight before roasting: 6.34 lbs Weight after roasting: 4.8 lbs Moisture loss: 24.2% Roasted at 250° 1. Temperature at ¼” below surface: 146° 2. Temperature at midpoint: 135° 3. Temperature at center: 125° Weight before roasting: 5.98 lbs Weight after roasting: 5.42 lbs Moisture loss: 9.38%”
― Cook's Illustrated Magazine, The Science of Good Cooking: Master 50 Simple Concepts to Enjoy a Lifetime of Success in the Kitchen

“FACT The pork of yesteryear was always cooked till gray, but that pork was a lot fattier than what’s on the market today. Selective breeding has made today’s pork much leaner, and if you cook it till gray, the meat will be dry and tough. We think the leanest cuts—like tenderloin—are best cooked to 145 degrees. At this point, the meat will still have a tinge of pink in the center. (Click here for more information about modern pork.)”
― Cook's Illustrated Magazine, The Cook's Illustrated Meat Book: The Game-Changing Guide That Teaches You How to Cook Meat and Poultry with 425 Bulletproof Recipes