D6 Epic offers a lot of variability for both players and GM's. The setting for the game can be anything from a medieval fantasy through to space opera, urban paranormal to traditional horror, cyber punk to steam punk. The characters also have the option for a great deal of variation as they're not stuck in a specific class. This allows the player to have a character who is a college professor, but is also a daring adventurer searching for relics.

The variation is only limited by the imagination of the GM and players.