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Ayyuce Demirbas

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A History of the Brain: From Stone Age surgery to modern neuroscience

by Andrew P. Wickens

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May 22, 2026 09:56AM

Ayyuce Demirbas is currently reading

The Ancient Origins of Consciousness: How the Brain Created Experience

by Todd E. Feinberg

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Apr 11, 2026 02:49PM

“It begins with the siRNA binding to a collection of proteins called the RNA-induced silencing complex (RISC). The RISC uses the siRNA as a template to search out matching mRNAs in the cell and degrade them. This serves both as a mechanism for regulating gene expression and as a defense against viruses. It also is a powerful tool for biology and medicine. It lets you temporarily “turn off” any gene you want. You can use it to treat a disease, or to study what happens when a gene is disabled. Just identify the mRNA you want to block, select any short segment of it, and create a siRNA molecule with the complementary sequence.”
― Bharath Ramsundar, Deep Learning for the Life Sciences: Applying Deep Learning to Genomics, Microscopy, Drug Discovery, and More

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“According to the classical view, at best one would expect to find copies of complete genes hidden within the ENCODE regions under study. As with the rest of the genome, gene transcripts made up only a fraction of the sequences. Instead, it turned out that not one percent but between 74 and 93 percent of the DNA was copied into RNA. Four out of every five bases had been transcribed into at least one RNA molecule. In other words, an enormous amount of “junk” must have been transcribed.”
― Bernhard Kegel, Epigenetik. Wie Erfahrungen vererbt werden

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“Auschwitz not only kills innocents; it kills innocence as well.”
― Antonio Iturbe, The Librarian of Auschwitz

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“Dazu gehörten nach Vorstellungen des Finanzministers nicht nur eine komplette Deindustrialisierung und Demilitarisierung Deutschlands, sondern auch harte Vergeltungsmaßnahmen gegen deutsche Kriegsverbrecher.”
― Annette Weinke, Die Nürnberger Prozesse

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“The smallest living things known, the viroids, are composed of less than 10,000 atoms. They cause several different diseases in cultivated plants and have probably most recently evolved from more complex organisms rather than from simpler ones. Indeed, it is hard to imagine a still simpler organism that is in any sense alive. Viroids are composed exclusively of nucleic acid, unlike the viruses, which also have a protein coat. They are no more than a single strand of RNA with either a linear or a closed circular geometry. Viroids can be so small and still thrive because they are thoroughgoing, unremitting parasites. Like viruses, they simply take over the molecular machinery of a much larger, well-functioning cell and change it from a factory for making more cells into a factory for making more viroids.”
― Carl Sagan, Cosmos

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