TOTO

“Most chemicals that give humans a buzz evolved to disrupt insect nervous systems. If our brains used different chemicals, we would not be so vulnerable. However, we have common ancestors with insects. It was long ago, about 500 million years ago, when our ancestors split off from the arthropod lines that became modern insects. However, our neurochemicals remain about the same as theirs. Fortunately, most plant neurotoxins don’t kill us. We have evolved to eat plants, and we are much larger than insects, so low doses are not fatal. But drugs can hijack our motivation mechanisms and take control of our lives.”
― Randolph M. Nesse, Good Reasons for Bad Feelings: Insights from the Frontier of Evolutionary Psychiatry

“So how does the massively complicated brain, with its eighty-six billion neurons, get built from such a small recipe book? The answer pivots on a clever strategy implemented by the genome: build incompletely and let world experience refine. Thus, for humans at birth, the brain is remarkably unfinished, and interaction with the world is necessary to complete it.”
― David Eagleman, Livewired: The Inside Story of the Ever-Changing Brain

“Ugly as hell, but it was the sort of thing only women would do to their hair, and so it was provocative.”
― Ursula K. Le Guin, The Word for World is Forest

“Criminalization and interdiction have filled prisons and corrupted governments in country after country. However, increasingly potent drugs that can be synthetized in any basement make controlling access increasingly impossible. Legalization seems like a good idea but causes more addiction. Our strongest defense is likely to be education, but scare stories make kids want to try drugs. Every child should learn that drugs take over the brain and turn some people into miserable zombies and that we have no way to tell who will get addicted the fastest. They should also learn that the high fades as addiction takes over.”
― Randolph M. Nesse, Good Reasons for Bad Feelings: Insights from the Frontier of Evolutionary Psychiatry