Walter

“It is true that vaccines have in the past taken a long, long time to develop. Until 2020, a new vaccine usually took at least ten years to develop from concept to roll-out. Many took much longer. The malaria vaccine programme at the Jenner Institute has been going for twenty-five years, and research into malaria vaccines had been going on for more than a hundred years – so far, with limited success. The lab-to-jab record-holder was the mumps vaccine, developed in four years by Maurice Hilleman in the United States in the 1960s.1 But the standard lengthy timeline we were all used to was never because vaccine development required ten, fifteen or thirty years of continuous painstaking lab work, clinical trials and data analysis. For every vaccine that had ever been developed up until 2020, most of the elapsed development time was spent waiting. In 2020, there were three key factors that enabled us to cut out the waiting and crunch ten years into one: first, the work we had already done; second, changes to the way funding was given out; and third, doing in parallel things that we would normally do in sequence.”
― Sarah Gilbert, Vaxxers: A Pioneering Moment in Scientific History

“Addiction If some scientists believe that “if-then” motivators and other extrinsic rewards resemble prescription drugs that carry potentially dangerous side effects, others believe they’re more like illegal drugs that foster a deeper and more pernicious dependency. According to these scholars, cash rewards and shiny trophies can provide a delicious jolt of pleasure at first, but the feeling soon dissipates—and to keep it alive, the recipient requires ever larger and more frequent doses. The Russian economist Anton Suvorov has constructed an elaborate econometric model to demonstrate this effect, configured around what’s called “principal-agent theory.” Think of the principal as the motivator—the employer, the teacher, the parent. Think of the agent as the motivatee—the employee, the student, the child. A principal essentially tries to get the agent to do what the principal wants, while the agent balances his own interests with whatever the principal is offering. Using a blizzard of complicated equations that test a variety of scenarios between principal and agent, Suvorov has reached conclusions that make intuitive sense to any parent who’s tried to get her kids to empty the garbage. By offering a reward, a principal signals to the agent that the task is undesirable. (If the task were desirable, the agent wouldn’t need a prod.) But that initial signal, and the reward that goes with it, forces the principal onto a path that’s difficult to leave. Offer too small a reward and the agent won’t comply. But offer a reward that’s enticing enough to get the agent to act the first time, and the principal “is doomed to give it again in the second.” There’s no going back. Pay your son to take out the trash—and you’ve pretty much guaranteed the kid will never do it again for free. What’s more, once the initial money buzz tapers off, you’ll likely have to increase the payment to continue compliance. As Suvorov explains, “Rewards are addictive in that once offered, a contingent reward makes an agent expect it whenever a similar task is faced, which in turn compels the principal to use rewards over and over again.” And before long, the existing reward may no longer suffice. It will quickly feel less like a bonus and more like the status quo—which then forces the principal to offer larger rewards to achieve the same effect.”
― Daniel H. Pink, Drive: The Surprising Truth About What Motivates Us

“In September 2020, Ruth Bader Ginsburg died. She had been a liberal judge on the US Supreme Court, and her death gave President Trump the opportunity to nominate an anti-abortion member of the religious right as her replacement. I am not going to say that abortion is a good thing, but it is sometimes a necessary thing and in a free society a woman should be able to choose if she is going to have an abortion or not. In an ideal world, it would not be necessary for very many abortions ever to be carried out. So an ideal world is what legislators should be looking to create if they want to reduce the number of abortions.”
― Sarah Gilbert, Vaxxers: A Pioneering Moment in Scientific History