Mark Henkel’s Reviews > Outlive: The Science & Art of Longevity > Status Update
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Mark Henkel
is on page 111 of 496
Ch.6 Complete
THE CRISIS OF ABUNDANCE
Can Our Ancient Genes Cope With Our Modern Diet?
ALT -& liver disease
You can't fight Horsemen without taking on
metabolic dysfunction first
Fat under skin not all bad,
but overflow is
Visceral Fat (between organs)
drives inflammation there,
& linked to cancer & cardiovasc disease
Inactivity causation
Preventing metabolic dysfunction is cornerstone to approach to longevity
— 19 hours, 59 min ago
THE CRISIS OF ABUNDANCE
Can Our Ancient Genes Cope With Our Modern Diet?
ALT -& liver disease
You can't fight Horsemen without taking on
metabolic dysfunction first
Fat under skin not all bad,
but overflow is
Visceral Fat (between organs)
drives inflammation there,
& linked to cancer & cardiovasc disease
Inactivity causation
Preventing metabolic dysfunction is cornerstone to approach to longevity
Mark Henkel
is on page 88 of 496
Ch.5 Complete
EAT LESS, LIVE LONGER?
The Science of Hunger and Health
On Easter Island (real name: Rapa Nui)
new molecule discovered, now known as
Rapamycin (after island's name)
R confirmed since 2009 to extend mouse lifespans reliably (and others)
mTOR
Calorie Reduction (CR) life-extending effect
AMPK is activated in exercise
Autophagy is essential to life
As we get older, it declines
Metformin shows promise
— Feb 07, 2026 08:05PM
EAT LESS, LIVE LONGER?
The Science of Hunger and Health
On Easter Island (real name: Rapa Nui)
new molecule discovered, now known as
Rapamycin (after island's name)
R confirmed since 2009 to extend mouse lifespans reliably (and others)
mTOR
Calorie Reduction (CR) life-extending effect
AMPK is activated in exercise
Autophagy is essential to life
As we get older, it declines
Metformin shows promise
Mark Henkel
is on page 73 of 496
Ch.4 Complete
CENTENARIANS
The Older Your Get,
The Healthier You Have Been
At 60, coronary arteries as 35yo's
At 85, looked & felt like 60
Goal of Med 3.0... to live like Centenarians
to enjoy 1, 2 even 3 Bonus Decades
Healthier at 90 than avg in 60s
Focus on delaying the ONSET
rather than extending DURATION
of all chronic diseases.
Goal is to live longer WITHOUT disease
Secret is RESILIENCE, we want to cultivate
— Feb 06, 2026 07:31PM
CENTENARIANS
The Older Your Get,
The Healthier You Have Been
At 60, coronary arteries as 35yo's
At 85, looked & felt like 60
Goal of Med 3.0... to live like Centenarians
to enjoy 1, 2 even 3 Bonus Decades
Healthier at 90 than avg in 60s
Focus on delaying the ONSET
rather than extending DURATION
of all chronic diseases.
Goal is to live longer WITHOUT disease
Secret is RESILIENCE, we want to cultivate
Mark Henkel
is on page 56 of 496
Ch.3 Complete
OBJECTIVE, STRATEGY, TACTICS
A Roadmap for Reading this Book
Strategy from 5 data sources:
centenarians
lifespan of "animal models"
human studies of 4 Horsemen
molecular & mechanistic studies of human & animal models (to drugs & exercise)
MR (Mendelian Randomization)
Like investment tactics for best ROI
get better than avg returns with acceptable risk,'
called ALPHA.
Achieve your own LONGEVITY ALPHA
— Feb 04, 2026 07:35PM
OBJECTIVE, STRATEGY, TACTICS
A Roadmap for Reading this Book
Strategy from 5 data sources:
centenarians
lifespan of "animal models"
human studies of 4 Horsemen
molecular & mechanistic studies of human & animal models (to drugs & exercise)
MR (Mendelian Randomization)
Like investment tactics for best ROI
get better than avg returns with acceptable risk,'
called ALPHA.
Achieve your own LONGEVITY ALPHA
Mark Henkel
is on page 56 of 496
Ch.3 Complete
OBJECTIVE, STRATEGY, TACTICS
A Roadmap for Reading this Book
x = Lifespan
y = Healthspan
Last decade > "Marginal Decade"
"Living longer means delaying death from ALL 4 of Horsemen
(cancer, diabetes, cardiovascular disorsers, & neurodegenerative diseases"
3 vectors or deterioration:
cognitive
physical
emotional health
5 Med 3.0 tactics:
exercise
nutrition
sleep
emotional health
exogenous molecules
— Feb 04, 2026 07:29PM
OBJECTIVE, STRATEGY, TACTICS
A Roadmap for Reading this Book
x = Lifespan
y = Healthspan
Last decade > "Marginal Decade"
"Living longer means delaying death from ALL 4 of Horsemen
(cancer, diabetes, cardiovascular disorsers, & neurodegenerative diseases"
3 vectors or deterioration:
cognitive
physical
emotional health
5 Med 3.0 tactics:
exercise
nutrition
sleep
emotional health
exogenous molecules
Mark Henkel
is on page 36 of 496
Ch.2 Complete
MEDICINE 3.0
Rethinking Medicine for the Age of Chronic Disease
"Medicine 3.0 pays far more attn to mantaining healthspan, the quality of life"
"Longevity, itself,
and healthspan in particular,
doesn't really fit into the business model of our current healthcare system"
"money flows to treatment rather than prevention" (<--EXACTLY!)
— Feb 04, 2026 07:22PM
MEDICINE 3.0
Rethinking Medicine for the Age of Chronic Disease
"Medicine 3.0 pays far more attn to mantaining healthspan, the quality of life"
"Longevity, itself,
and healthspan in particular,
doesn't really fit into the business model of our current healthcare system"
"money flows to treatment rather than prevention" (<--EXACTLY!)
Mark Henkel
is on page 36 of 496
Ch.2 Complete
MEDICINE 3.0
Rethinking Medicine for the Age of Chronic Disease
Medicine 1.0 = conclusions based on observations & guesswork
(no by more by "the gods")
2.0 = mid1800s - germ theory of disease, adding hypothesis to steps
AFTER DISEASE NOTED
100yrs less successful against longterm disease like cancer
3.0 = prevent tumors (etc) starting spreading in first place
emphasis: PREVENTION, quality of life
— Feb 04, 2026 07:19PM
MEDICINE 3.0
Rethinking Medicine for the Age of Chronic Disease
Medicine 1.0 = conclusions based on observations & guesswork
(no by more by "the gods")
2.0 = mid1800s - germ theory of disease, adding hypothesis to steps
AFTER DISEASE NOTED
100yrs less successful against longterm disease like cancer
3.0 = prevent tumors (etc) starting spreading in first place
emphasis: PREVENTION, quality of life
